Cyclin D1 expression in Peripheral T-Cell Lymphoma: A report of 2 cases

: Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of non-Hodgkin's (NHL), characterized by poor outcome, accounting approximately for 10%-15% all non-Hodgkin in the western countries, and with higher prevalence Asia. Cyclin D1 immunoreactivity is characteristically seen mantle cell lymphoma. It also observed hairy leukemia, plasma myeloma proportion diffuse large B-cell lymphomas, however its expression peripheral lymphoma rarely recorded. We report two cases not otherwise specified nuclear immunohistochemical overexpression, due to gene copy gain, phenomenon similar that Mantle Cell Lymphoma. can be PTCLs, besides lymphoma, leukemia underline importance molecular biology integration tests as diagnostic tool escape pitfall.